Article
Influence of CCND1 G870A polymorphism on the risk of HBV-related HCC and cyclin D1 splicing variant expression in Chinese population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2015
Zeng Zhenzhen, Tu Jing, Cheng Jin, Yao Mingjie, Wu Yali, Huang Xiangbo, Xie Xiaomeng, Zhang Xiaolei, Lu Fengmin, Chen Xiangmei
Abstract excerpt
The G870A polymorphism in the exon 4/intron 4 boundary of CCND1 gene is thought to influence the generation of two mRNAs (cyclin D1a and cyclin D1b). The "A" allele codes for a truncated variant, cyclin D1b, which may have higher transforming activity. Herein, the tumor relevance of G870A polymorphism, the association between cyclin D1 variant expression and G870A genotype, and the oncogenic potential of cyclin...
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