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Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4 / CyclinD1‐pRB‐E2F1 pathway

13 Mar 2023

Abstract excerpt

Cyclin D1 (CCND1), a mediator of cell cycle control, has a G870A polymorphism which results in the formation of two splicing variants: full-length CCND1 (CCND1a) and C-terminally truncated CCND1 species (CCND1b). However, the role of CCND1a and CCND1b variants in cancer chemoresistance remains unknown. Therefore, this study aimed to explore the molecular mechanism of alternative splicing of CCND1 in breast cancer...

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Cancer Genomics and Diagnostics
Cancer-related Molecular Pathways
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36915230
DOI: 10.1111/jcmm.17716

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