Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

4 Nov 2023

Abstract excerpt

Precision oncology approaches for patients with colorectal cancer (CRC) continue to lag behind other solid cancers. Functional precision oncology-a strategy that is based on perturbing primary tumor cells from cancer patients-could provide a road forward to personalize treatment. We extend this paradigm to measuring proteome activity landscapes by acquiring quantitative phosphoproteomic data from patient-derived...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 38047086
DOI: 10.1016/j.isci.2023.108399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancerPMID 38047086Read ↗

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancerSemantic proximity Read ↗

Oncogenic signaling is coupled to colorectal cancer cell differentiation state.Semantic proximity Read ↗

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discoverySemantic proximity Read ↗

Dissection and reconstruction of the colorectal cancer tumor microenvironmentSemantic proximity Read ↗

From Genomic Alterations to Functional Tumor Biology: Integrating Organoids and Organ-on-a-Chip in Colorectal Cancer.Semantic proximity Read ↗

Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTENSemantic proximity Read ↗

Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocksSemantic proximity Read ↗

Prospective pan-cancer phosphoproteomics at clinical scale extends therapeutic options in precision oncologySemantic proximity Read ↗

The drug-induced phenotypic landscape of colorectal cancer organoidsSemantic proximity Read ↗

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancerSemantic proximity Read ↗

The drug-induced phenotypic landscape of colorectal cancer organoids.Semantic proximity Read ↗

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.