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Article

The role of IGF-1R in pediatric malignancies.

The oncologist - 1 Jan 2009

Kim Su Young, Toretsky Jeffrey A, Scher Daniel, Helman Lee J

Abstract excerpt

The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed...

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Identifiers

PMID: 19126579
DOI: 10.1634/theoncologist.2008-0189
PMCID: PMC2721475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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