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Article

Emergence of heterogeneity in acute leukemias.

Biology direct - 12 Oct 2016

Stiehl Thomas, Lutz Christoph, Marciniak-Czochra Anna

Abstract excerpt

BACKGROUND: Leukemias are malignant proliferative disorders of the blood forming system. Sequencing studies demonstrate that the leukemic cell population consists of multiple clones. The genetic relationship between the different clones, referred to as the clonal hierarchy, shows high interindividual variability. So far, the source of this heterogeneity and its clinical relevance remain unknown. We propose a...

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Identifiers

PMID: 27733173
DOI: 10.1186/s13062-016-0154-1
PMCID: PMC5062896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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