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Article

An evolutionary perspective on chronic myelomonocytic leukemia.

Leukemia - 1 Jul 2013

Itzykson R, Solary E

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) shares with other myeloid diseases a number of somatic gene mutations. These mutations can now be integrated within the framework of evolution theory to address the mechanisms of the disease. Several evidences indicate that the disease emerges in adult hematopoietic stem cells (HSC) through the age-dependent accumulation of DNA damage, leading stochastically to a driver...

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Share to Acute Myeloid Leukemia Research
Share to Clonal Evolution
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

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Share to Leukemia, Myelomonocytic, Chronic

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Source

Identifiers

PMID: 23558522
DOI: 10.1038/leu.2013.100

Genes

SRSF2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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