Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epistasis decreases with increasing antibiotic pressure but not temperature.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 22 May 2023

Ghenu Ana-Hermina, Amado André, Gordo Isabel, Bank Claudia

Abstract excerpt

Predicting mutational effects is essential for the control of antibiotic resistance (ABR). Predictions are difficult when there are strong genotype-by-environment (G × E), gene-by-gene (G × G or epistatic) or gene-by-gene-by-environment (G × G × E) interactions. We quantified G × G × E effects in Escherichia coli across environmental gradients. We created intergenic fitness landscapes using gene knock-outs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genetic Fitness

Share to Genotype

Share to Mutation

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 37004727
DOI: 10.1098/rstb.2022.0058
PMCID: PMC10067269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epistasis decreases with increasing antibiotic pressure but not temperature.PMID 37004727Read ↗

The environment affects epistatic interactions to alter the topology of an empirical fitness landscape.Semantic proximity Read ↗

High-dimensional Characterization of Genome–Environment Fitness Landscapes in <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Predictable Phenotypes of Antibiotic Resistance Mutations.Semantic proximity Read ↗

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.Semantic proximity Read ↗

Differential strengths of molecular determinants guide environment specific mutational fates.Semantic proximity Read ↗

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance.Semantic proximity Read ↗

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistanceSemantic proximity Read ↗

Multi-environment fitness landscapes of a tRNA gene.Semantic proximity Read ↗

Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistanceSemantic proximity Read ↗

Environment-by-Environment Interactions Differ Across Genetic Backgrounds.Semantic proximity Read ↗

Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes.Semantic proximity Read ↗

Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.