Ultrasensitive detection of tumor-specific mutations in saliva of patients with oral cavity squamous cell carcinoma.

doi:10.1002/cncr.33393

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Article

Ultrasensitive detection of tumor-specific mutations in saliva of patients with oral cavity squamous cell carcinoma.

Cancer - 15 May 2021

Shanmugam Ashwini, Hariharan Arun K, Hasina Rifat, Nair Jayalakshmi R, Katragadda Shanmukh, Irusappan Sivaraj, Ravichandran Aarthi, Veeramachaneni Vamsi, Bettadapura Radhakrishna, Bhati Muddasir, Ramaswamy Veena, Rao Vishal U S, Bagadia Ritvi K, Manjunath Ashwini, Manjunath N M L, Solomon Monica Charlotte, Maji Shiuli, Bahadur Urvashi, Bettegowda Chetan, Papadopoulos Nickolas, Lingen Mark W, Hariharan Ramesh, Gupta Vaijayanti, Agrawal Nishant, Izumchenko Evgeny

Abstract excerpt

BACKGROUND: Oral cavity squamous cell carcinoma (OCSCC) is the most common head and neck malignancy. Although the survival rate of patients with advanced-stage disease remains approximately 20% to 60%, when detected at an early stage, the survival rate approaches 80%, posing a pressing need for a well validated profiling method to assess patients who have a high risk of developing OCSCC. Tumor DNA detection in...

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Identifiers

PMID: 33405231
DOI: 10.1002/cncr.33393
PMCID: PMC8084899

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