Back to search

Article

Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk

2019-08-06

Abstract excerpt

<h4>Background</h4> The study of biological age acceleration may help identify at-risk individuals and contribute to reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging in schizophrenia (SCZ), a severe mental illness that is associated with an increased prevalence of age-related disabilities and morbidities. In a multi-cohort whole blood s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2f5165a5-fe49-543b-a7e1-4e77f6057ad6
DOI
10.1101/727859
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease riskDOI 10.1101/727859
Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patientsSemantic proximity
Epigenetic Age Acceleration Was Delayed in SchizophreniaSemantic proximity
Epigenetic clock analysis of blood samples from Japanese schizophrenia patientsSemantic proximity
Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophreniaSemantic proximity
Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity
Methylation age acceleration does not predict mortality in schizophreniaSemantic proximity
Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosisSemantic proximity
Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.Semantic proximity
How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated agingSemantic proximity
The Epigenetic Landscape: From Molecular Mechanisms to Biological AgingSemantic proximity
DNA methylation clocks for estimating biological age in Chinese cohortsSemantic proximity
Properties of the epigenetic clock and age accelerationSemantic proximity
Select a neighboring publication to make it the new centre.