Article
Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse.
Aging cell - 1 Dec 2015
Victoria Berta, Dhahbi Joseph M, Nunez Lopez Yury O, Spinel Lina, Atamna Hani, Spindler Stephen R, Masternak Michal M
Abstract excerpt
Recent evidence demonstrates that serum levels of specific miRNAs significantly change with age. The ability of circulating sncRNAs to act as signaling molecules and regulate a broad spectrum of cellular functions implicates them as key players in the aging process. To discover circulating sncRNAs that impact aging in the long-lived Ames dwarf mice, we conducted deep sequencing of small RNAs extracted from serum...
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