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Article

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

12 Mar 2014

Abstract excerpt

The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in young. With aging, p85α, IGF-1 and B-myb muscle levels were lower while the expression of certain cell arrest proteins (p53, p16 and pRB) increased. When miR-29 was expressed in muscle...

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PMID: 24659628
DOI: 10.18632/aging.100643

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