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Article

VNTR Polymorphism in the Intron 5 of SIRT3 and Susceptibility to Breast Cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Mar 2023

Payavula Harshitha Yadav, Jamadandu Deepika, Velpula Salomy, Digumarti Raghunadha Rao, Satti Vishnupriya, Annamaneni Sandhya

Abstract excerpt

BACKGROUND: Breast cancer recurrence and metastasis are associated with alterations in the cellular stress responses that influence tumour signalling. Sirtuin3 (SIRT3), a mitochondrial deacetylase is the regulator of mitochondrial metabolism and oxidative stress affecting tumour cell responses. Genetic variants or dysregulation of SIRT3 was known to associate with poor prognosis of recurrence and relapse in few...

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Identifiers

PMID: 36974538
DOI: 10.31557/APJCP.2023.24.3.859
PMCID: PMC10334083

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