Article
Association of HLA-G 3'UTR 14-bp Ins/Del polymorphism with breast cancer among South Indian women.
Journal of clinical pathology - 1 Aug 2020
Kadiam Sony, Ramasamy Thirunavukkarasu, Ramakrishnan Revathi, Mariakuttikan Jayalakshmi
Abstract excerpt
AIM: Human leucocyte antigen-G (HLA-G) and tumour necrosis factor-alpha (TNF-α) are potent immune mediators implicated in the pathogenesis of breast cancer. The polymorphisms in the 3' untranslated region (3'UTR) of HLA-G and promoter region of TNF-α are well known to influence their expression levels and may consequently contribute to varied disease predisposition. Therefore, in the present study, we explored...
Topics
- 3' Untranslated Regions
- Adult
- Aged
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- HLA-G Antigens
- Haplotypes
- Humans
- India
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- Tumor Necrosis Factor-alpha