Article
Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation.
PLoS genetics - 1 Mar 2023
McHenry Michael L, Simmons Jason, Hong Hyejeong, Malone LaShaunda L, Mayanja-Kizza Harriet, Bush William S, Boom W Henry, Hawn Thomas R, Williams Scott M, Stein Catherine M
Abstract excerpt
BACKGROUND: Tuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a large proportion of genetic risk for adult pulmonary TB, and even fewer have examined genetic factors underlying TB severity, an intermediate trait impacting disease experience, quality of life, and risk of mortality. No prior severity analyses...
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