Article

Immunopathogenic Overlap and Shared Therapeutic Targets for Covid-19 and Tuberculosis Predicted from Transcriptomic Meta-Analysis

2021-03-30

Abstract excerpt

Current and previous tuberculosis (TB) increase the risk for severe and fatal COVID-19. To identify mechanisms of immunopathogenic interaction which may increase severity of COVID-19 and determine the impact of co-infection on subsequent TB progression, we performed a systematic review and patient-level meta-analysis of COVID-19 transcriptomic signatures, spanning mild-critical disease, from whole blood, PBMCs and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 539ebf84-3b5a-5de3-8fd2-54fd7cbbbf15
DOI: 10.2139/ssrn.3815987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunopathogenic Overlap and Shared Therapeutic Targets for Covid-19 and Tuberculosis Predicted from Transcriptomic Meta-AnalysisDOI 10.2139/ssrn.3815987Read

Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infectionSemantic proximity Read

Systematic evaluation of transcriptomic disease risk and diagnostic biomarker overlap between COVID-19 and tuberculosis: a patient-level meta-analysisSemantic proximity Read

Exploring of the shared gene signatures and molecular mechanism in COVID-19 and tuberculosisSemantic proximity Read

Dissecting the effect of single- and co-infection of TB and COVID-19 pathogens on the sputum microbiomeSemantic proximity Read

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read

Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available DatasetsSemantic proximity Read

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis CoinfectionSemantic proximity Read

Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosisSemantic proximity Read

Clustering Mycobacterium tuberculosis-specific CD154+CD4+ T cells for distinguishing tuberculosis disease from infection based on single-cell RNA-seq analysisSemantic proximity Read

Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human MacrophagesSemantic proximity Read

Comprehensive identification of immuno-related transcriptional signature for active pulmonary tuberculosis by integrated analysis of array and single cell RNA-seqSemantic proximity Read

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.Semantic proximity Read