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Article

Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts.

EBioMedicine - 1 Mar 2023

Xin Junyi, Jiang Xia, Li Huiqin, Chen Silu, Zhang Zhengdong, Wang Meilin, Gu Dongying, Du Mulong, Christiani David C

Abstract excerpt

BACKGROUND: Polygenic risk score (PRS) has been demonstrated to be effective in identifying individuals at high risk of developing cancer, but its prognostic value remains unclear. METHODS: We constructed site-specific PRSs by aggregating the risk effect of independent variants derived from previous genome-wide association studies (GWASs) across 17 cancer types. The Cox proportional hazards model was used to...

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Identifiers

PMID: 36739632
DOI: 10.1016/j.ebiom.2023.104454
PMCID: PMC9931923

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