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Article

A self-propagating, barcoded transposon system for the dynamic rewiring of genomic networks.

Molecular systems biology - 12 Jun 2023

English Max A, Alcantar Miguel A, Collins James J

Abstract excerpt

In bacteria, natural transposon mobilization can drive adaptive genomic rearrangements. Here, we build on this capability and develop an inducible, self-propagating transposon platform for continuous genome-wide mutagenesis and the dynamic rewiring of gene networks in bacteria. We first use the platform to study the impact of transposon functionalization on the evolution of parallel Escherichia coli populations...

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Identifiers

PMID: 36970845
DOI: 10.15252/msb.202211398
PMCID: PMC10258560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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