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Article

Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities.

Cell metabolism - 2 Jul 2024

Kim Min Seo, Shim Injeong, Fahed Akl C, Do Ron, Park Woong-Yang, Natarajan Pradeep, Khera Amit V, Won Hong-Hee

Abstract excerpt

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity and obesity-related morbidities remains unknown. We explored how the interaction between genetic and lifestyle factors influences the risk of obesity and obesity-related morbidities. The polygenic score for body mass index was calculated to quantify inherited susceptibility to obesity in 338,645 UK Biobank European...

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PMID: 38959863
DOI: 10.1016/j.cmet.2024.06.004

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