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Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring

23 Mar 2023

Abstract excerpt

Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ malignancies, and dermatologic diseases. Although it is highly contraindicated for pregnant women, because it is associated with an increased risk of multiple birth defects, the effect of paternal MTX exposure on their offspring has...

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PMID: 36959185
DOI: 10.1038/s41467-023-37427-7

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