Article

Physiologic variation in sperm miRNAs tune embryonic gene regulatory programs and developmental outcomes

2026-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Small RNAs delivered by sperm can transmit environmentally regulated, epigenetically inherited phenotypes to offspring, yet the mechanisms by which modest changes in sperm microRNA abundance overcome dilution within the much larger egg to influence embryonic development remain unresolved. Here, we show that physiologically relevant variation in individual sperm miRNAs is sufficient to quantitati...

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Literature Corpus work: 01ee4625-d6cc-54b8-ac49-d184b849d3f7
DOI: 10.64898/2026.03.04.709527

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