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Article

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans.

Nature communications - 15 Mar 2026

Galambos Nicholas S, Crocker Olivia J, Schneider Blair K, Allerton Kennelly S, Gross Katrin E, Schneider Alexandra E, Lynch Jared, Yukselen Onur, Kucukural Alper, Conine Colin C

Abstract excerpt

The environment encountered by an organism can modulate epigenetic information in gametes to transmit non-genetically inherited phenotypes to offspring. In mouse models, the diet of males regulates specific tRNA-derived RNAs (tDRs) in sperm. After fertilization, tDRs regulate embryonic gene expression and generate metabolic phenotypes in adult offspring through uncharacterized changes during development. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41833931
DOI: 10.1038/s41467-026-70029-7
PMCID: PMC13136342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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