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Article

Dnmt2-null sperm block maternal transmission of a paramutant phenotype†.

Biology of reproduction - 14 Sept 2021

Yu Tian, Xie Yeming, Tang Chong, Wang Yue, Yuan Shuiqiao, Zheng Huili, Yan Wei

Abstract excerpt

Previous studies have shown that Dnmt2-null sperm block the paternal transmission (through sperm) of certain acquired traits, e.g., high-fat diet-induced metabolic disorders or white tails due to a Kit paramutation. Here, we report that DNMT2 is also required for the transmission of a Kit paramutant phenotype (white tail tip) through the female germline (i.e., oocytes). Specifically, ablation of Dnmt2 led to...

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Identifiers

PMID: 33929014
DOI: 10.1093/biolre/ioab086
PMCID: PMC8444667

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