Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

doi:10.1038/s41556-018-0087-2

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Article

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

Nature cell biology - 1 May 2018

Zhang Yunfang, Zhang Xudong, Shi Junchao, Tuorto Francesca, Li Xin, Liu Yusheng, Liebers Reinhard, Zhang Liwen, Qu Yongcun, Qian Jingjing, Pahima Maya, Liu Ying, Yan Menghong, Cao Zhonghong, Lei Xiaohua, Cao Yujing, Peng Hongying, Liu Shichao, Wang Yue, Zheng Huili, Woolsey Rebekah, Quilici David, Zhai Qiwei, Li Lei, Zhou Tong, Yan Wei, Lyko Frank, Zhang Ying, Zhou Qi, Duan Enkui, Chen Qi

Abstract excerpt

The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA 1 . Increasing evidence now suggests that sperm small non-coding RNAs (sncRNAs) can mediate intergenerational transmission of paternally acquired phenotypes, including mental stress2,3 and metabolic...

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PMID: 29695786
DOI: 10.1038/s41556-018-0087-2
PMCID: PMC5926820

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