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Article

Genetic insights into modifiable risk factors of stroke and their joint effects: A genome-wide pleiotropic analysis.

Neuroscience - 15 Dec 2025

Yang Zewen, Liu Hanchen, Zhang Guanghao, Ma Hongyu, Wang Lijun, Liu Guoping, Huang Qinghai, Zhou Yu, Yang Pengfei, Liu Jianmin

Abstract excerpt

OBJECTIVE: Epidemiologic and genetic associations of modifiable risk factors with stroke have been widely reported. However, the degree to which the shared genetic determinants are involved in these associations is unclear. Our study aimed to investigate the shared genetic etiology between stroke and its leading risk factors and to identify shared genomic loci, genes, and pathways that are widely distributed...

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Topics

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Share to ALDH2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 41248841
DOI: 10.1016/j.neuroscience.2025.11.012

Genes

ACAD10
ALDH2
ATXN2
NT5C2
SH2B3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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