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Article

Exercise, APOE genotype, and the evolution of the human lifespan.

Trends in neurosciences - 1 May 2014

Raichlen David A, Alexander Gene E

Abstract excerpt

Humans have exceptionally long lifespans compared with other mammals. However, our longevity evolved when our ancestors had two copies of the apolipoprotein E (APOE) ɛ4 allele, a genotype that leads to a high risk of Alzheimer's disease (AD), cardiovascular disease, and increased mortality. How did human aging evolve within this genetic constraint? Drawing from neuroscience, anthropology, and brain-imaging...

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Source

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Identifiers

PMID: 24690272
DOI: 10.1016/j.tins.2014.03.001
PMCID: PMC4066890

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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