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Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history

21 Apr 2010

Abstract excerpt

The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with increased cholesterol levels and heart disease. Population allele frequencies of APOE have previously been shown to vary, with epsilon4 frequencies generally increasing with latitude. We hypothesize that this trend resulted from natural selection protecting against low-cholesterol levels. In high-latitude cold environments and low-latitude...

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PMID: 20734437
DOI: 10.1002/ajpa.21298

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