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Testing algorithm for identification of patients with TRK fusion cancer

9 May 2019

Abstract excerpt

The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous system development and function. NTRK gene fusions are oncogenic drivers of various adult and paediatric tumours. Several methods have been used to detect NTRK gene fusions including immunohistochemistry, fluorescence in situ hybridisation,...

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PMID: 31072837
DOI: 10.1136/jclinpath-2018-205679

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