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Article

Prevalence of neurotrophic tropomyosin receptor kinase ( NTRK ) fusion gene positivity in patients with solid tumors in Japan

1 Jun 2024

Abstract excerpt

BACKGROUND: Members of the neurotrophic tropomyosin receptor kinase (NTRK) gene family, NTRK1, NTRK2, and NTRK3 encode TRK receptor tyrosine kinases. Intra- or inter-chromosomal gene rearrangements produce NTRK gene fusions encoding fusion proteins which are oncogenic drivers in various solid tumors. METHODS: This study investigated the prevalence of NTRK fusion genes and identified fusion partners in Japanese...

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Identifiers

PMID: 38925616
DOI: 10.1002/cam4.7351

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