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NTRK fusion in Japanese colorectal adenocarcinomas

11 Mar 2021

Abstract excerpt

NTRK fusion-positive tumors are known to be highly sensitive to TRK inhibitors, such as larotrectinib and entrectinib. Therefore, identification of patients who can potentially benefit from these inhibitors is important; however, the frequency of NTRK fusions in Japanese patients with colorectal cancer (CRC) is unknown. We performed pan-TRK staining using TMA-based immunohistochemistry (IHC) on samples from 971...

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PMID: 33707574
DOI: 10.1038/s41598-021-85075-y

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