Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.

doi:10.1371/journal.pone.0248886

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Article

Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.

PloS one - 1 Jan 2021

Mosquera Orgueira Adrián, Ferreiro Ferro Roi, Díaz Arias José Ángel, Aliste Santos Carlos, Antelo Rodríguez Beatriz, Bao Pérez Laura, Alonso Vence Natalia, Bendaña López Ággeles, Abuin Blanco Aitor, Melero Valentín Paula, Peleteiro Raindo And Res, Cid López Miguel, Pérez Encinas Manuel Mateo, González Pérez Marta Sonia, Fraga Rodríguez Máximo Francisco, Bello López José Luis

Abstract excerpt

B-cell lymphoproliferative disorders exhibit a diverse spectrum of diagnostic entities with heterogeneous behaviour. Multiple efforts have focused on the determination of the genomic drivers of B-cell lymphoma subtypes. In the meantime, the aggregation of diverse tumors in pan-cancer genomic studies has become a useful tool to detect new driver genes, while enabling the comparison of mutational patterns across...

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PMID: 33945543
DOI: 10.1371/journal.pone.0248886
PMCID: PMC8096002

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