Article
The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells.
British journal of haematology - 1 Mar 2022
Haebe Sarah, Keay William, Alig Stefan, Mohr Anne-Wiebe, Martin Larissa K, Heide Michael, Secci Ramona, Krebs Stefan, Blum Helmut, Moosmann Andreas, Louissaint Abner, Weinstock David M, Thoene Silvia, von Bergwelt-Baildon Michael, Ruland Jürgen, Bararia Deepak, Weigert Oliver
Abstract excerpt
Relapsed follicular lymphoma (FL) can arise from common progenitor cells (CPCs). Conceptually, CPC-defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B-cell leukaemia/lymphoma 2 (BCL2)/immunoglobulin heavy locus (IGH) translocations and other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find CPC-defining...
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