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Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates

16 Mar 2023

Abstract excerpt

The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical for differential propagation and toxicity. Based on these findings, we have compared, for the first time, in this pilot study, the capacity of two alpha-synuclein strains and patient-derived Lewy body...

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PMID: 36933673
DOI: 10.1016/j.nbd.2023.106086

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