Article

Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains

2025-06-07

Abstract excerpt

The existence of α-synuclein conformational strains provides a potential explanation for the clinical and pathological differences among synucleinopathies such as Parkinson’s disease and multiple system atrophy. However, how distinct α-synuclein strains are formed in vivo remains unknown. Here, we examined whether unique strains of self-propagating α-synuclein aggregates can arise within a consistent molecular en...

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Literature Corpus work: ff9c4454-6309-51aa-9db8-529b9e9ccca4
DOI: 10.1101/2025.06.03.657690

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