Article
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Acta neuropathologica communications - 3 May 2023
Lau Heather H C, Martinez-Valbuena Ivan, So Raphaella W L, Mehra Surabhi, Silver Nicholas R G, Mao Alison, Stuart Erica, Schmitt-Ulms Cian, Hyman Bradley T, Ingelsson Martin, Kovacs Gabor G, Watts Joel C
Abstract excerpt
Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of oligodendroglial α-synuclein inclusions, α-synuclein aggregates in Parkinson's disease (PD) preferentially accumulate in neurons. The G51D mutation in the SNCA gene encoding...
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