Article

α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome

2020-03-20

Abstract excerpt

Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether differences in the strains of α-synuclein aggregates account for the different pathologies remained unclear. Here, we generated two types of α-synuclein fibrils from ide...

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Literature Corpus work: 78b3b84b-865f-5377-adfb-f679388e1a1d
DOI: 10.1101/2020.03.19.999086

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