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Article

The trouble with triples: Examining the impact of measurement error in mediation analysis.

Genetics - 4 May 2023

Gastonguay Madeleine S, Keele Gregory R, Churchill Gary A

Abstract excerpt

Mediation analysis is used in genetic mapping studies to identify candidate gene mediators of quantitative trait loci (QTL). We consider genetic mediation analysis of triplets-sets of three variables consisting of a target trait, the genotype at a QTL for the target trait, and a candidate mediator that is the abundance of a transcript or protein whose coding gene co-locates with the QTL. We show that, in the...

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Identifiers

PMID: 36932658
DOI: 10.1093/genetics/iyad045
PMCID: PMC10158839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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