Back to search

Article

Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics

2023-07-05

Abstract excerpt

Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity that affects millions of individuals worldwide. The complex pathophysiology of CRS remains poorly understood, with emerging evidence implicating the orchestration between diverse immune and epithelial cell types in disease progression. We applied single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to both dissociat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a614d89d-2f2e-52ef-9844-6f5e46bcf210
DOI
10.1101/2023.07.01.547352
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled TranscriptomicsDOI 10.1101/2023.07.01.547352
Single cell transcriptomic analysis reveals transcriptome differences of different cells between eosinophilic chronic rhinosinusitis with nasal polyps and non-eosinophilic chronic rhinosinusitis with nasal polypsSemantic proximity
Transcriptomic Differentiation of Phenotypes in Chronic Rhinosinusitis and Its Implications for Understanding the Underlying Mechanisms.Semantic proximity
The global transcriptomic signature in sinonasal tissues reveals roles for tissue type and chronic rhinosinusitis disease phenotype.Semantic proximity
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndromeSemantic proximity
Single-cell RNA sequencing reveals the epithelial cell, fibroblast, and key gene alterations in chronic rhinosinusitis with nasal polypsSemantic proximity
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunitySemantic proximity
Endotyping in Chronic Rhinosinusitis-An EAACI Task Force Report.Semantic proximity
FCGR3A+CD8+ cytotoxic T effector subset with NK-cell-like features promotes disease progression in eosinophilic chronic rhinosinusitis with nasal polypsSemantic proximity
Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polypsSemantic proximity
Comparative genomic analysis reveals shared and distinct mechanisms of nasal polyps and chronic rhinosinusitisSemantic proximity
A Deep Learning–Enabled Single-Cell Morpholomic Atlas of Nasal Swabs Distinguishes Chronic Inflammation from Sinonasal MalignancySemantic proximity
Transcriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis with Nasal PolypsSemantic proximity
Select a neighboring publication to make it the new centre.