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Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway

11 Mar 2019

Abstract excerpt

IgE is secreted by plasma cells (PCs) and is central to allergic disease. Using an ex vivo tonsil B cell culture system, which mimics the Th2 responses in vivo, we have recently characterized the development pathway of human IgE-expressing PCs. In this system, as in mice, we reported the predisposition of IgE-expressing B cells to differentiate into PCs. To gain a comprehensive understanding of the molecular...

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PMID: 30915071
DOI: 10.3389/fimmu.2019.00402

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