Article
Ontogeny of human IgE-expressing B cells and plasma cells.
Allergy - 1 Jan 2017
Ramadani F, Bowen H, Upton N, Hobson P S, Chan Y-C, Chen J-B, Chang T W, McDonnell J M, Sutton B J, Fear D J, Gould H J
Abstract excerpt
BACKGROUND: IgE-expressing (IgE+ ) plasma cells (PCs) provide a continuous source of allergen-specific IgE that is central to allergic responses. The extreme sparsity of IgE+ cells in vivo has confined their study almost entirely to mouse models. OBJECTIVE: To characterize the development pathway of human IgE+ PCs and to determine the ontogeny of human IgE+ PCs. METHODS: To generate human IgE+ cells, we cultured...
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