Article
Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism.
Biochemical and biophysical research communications - 17 Feb 2006
Saywell Véronique, Viola Angèle, Confort-Gouny Sylviane, Le Fur Yann, Villard Laurent, Cozzone Patrick J
Abstract excerpt
Rett syndrome, a neurodevelopmental X-linked disorder, represents the most important genetic cause of severe mental retardation in the female population and results from a mutation in the gene encoding methyl-CpG-binding protein 2 (MECP2). We report here the first characterization of Mecp2-null mice, by in vivo magnetic resonance imaging and spectroscopy, delineating the cerebral phenotype associated with the...
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