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Early diagnosis of brain metastases using cerebrospinal fluid cell‐free DNA‐based breakpoint motif and mutational features in lung cancer

1 Mar 2023

Abstract excerpt

In this study, we developed a sensitive machine learning model with a remarkable capacity to predict brain metastases (BM) in lung cancer patients using the breakpoint motif (BPM) features in cerebrospinal fluid (CSF) circulating tumour DNA (ctDNA). We have also assessed the mutational profile in CSF ctDNA, revealing promising BM-related prognostic biomarkers in lung cancer patients. BM is frequently associated...

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PMID: 36929639
DOI: 10.1002/ctm2.1221

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