Article
Utilizing phenotypic characteristics of metastatic brain tumors to improve the probability of detecting circulating tumor DNA from cerebrospinal fluid in non-small-cell lung cancer patients: development and validation of a prediction model in a prospective cohort study.
ESMO open - 1 Feb 2022
Li M, Hou X, Zheng L, Ma Y, Li D, Lv Y, Chen J, Zheng W, Shao Y, Mou Y, Chen L
Abstract excerpt
BACKGROUND: Circulating tumor DNA (ctDNA) in cerebrospinal fluid (CSF) has become a promising surrogate for genomic profiling of central nervous system tumors. However, suboptimal ctDNA detection rates from CSF limit its clinical utility. Thus precise screening of suitable patients is needed to maximize the clinical benefit. PATIENTS AND METHODS: Between February 2017 and December 2020, 66 newly diagnosed...
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