Article
Five genes identified as prognostic markers for colorectal cancer through the integration of genome-wide association study and expression quantitative trait loci data.
Personalized medicine - 1 Jan 2024
Zhang Cuizhen, Huang Wenjie, Niu Wanjie, Yang Huiying, Zheng Yingyi, Gao Xuan, Qiu Xiaoyan
Abstract excerpt
Background: Colorectal cancer (CRC) is a prominent form of cancer globally, ranking second in terms of prevalence and serving as a leading cause of cancer-related deaths, but the underlying biological interpretation remains largely unknown. Methods: We used the summary data-based Mendelian randomization method to integrate CRC genome-wide association studies (ncase = 7062; ncontrol = 195,745) and expression...
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