Article
Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
Gut - 1 May 2014
Cheng Iona, Kocarnik Jonathan M, Dumitrescu Logan, Lindor Noralane M, Chang-Claude Jenny, Avery Christy L, Caberto Christian P, Love Shelly-Ann, Slattery Martha L, Chan Andrew T, Baron John A, Hindorff Lucia A, Park Sungshim Lani, Schumacher Fredrick R, Hoffmeister Michael, Kraft Peter, Butler Anne M, Duggan David J, Hou Lifang, Carlson Chris S, Monroe Kristine R, Lin Yi, Carty Cara L, Mann Sue, Ma Jing, Giovannucci Edward L, Fuchs Charles S, Newcomb Polly A, Jenkins Mark A, Hopper John L, Haile Robert W, Conti David V, Campbell Peter T, Potter John D, Caan Bette J, Schoen Robert E, Hayes Richard B, Chanock Stephen J, Berndt Sonja I, Küry Sebastien, Bézieau Stephane, Ambite Jose Luis, Kumaraguruparan Gowri, Richardson Danielle M, Goodloe Robert J, Dilks Holli H, Baker Paxton, Zanke Brent W, Lemire Mathieu, Gallinger Steven, Hsu Li, Jiao Shuo, Harrison Tabitha A, Seminara Daniela, Haiman Christopher A, Kooperberg Charles, Wilkens Lynne R, Hutter Carolyn M, White Emily, Crawford Dana C, Heiss Gerardo, Hudson Thomas J, Brenner Hermann, Bush William S, Casey Graham, Le Marchand Loïc, Peters Ulrike
Abstract excerpt
OBJECTIVE: Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be...
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