Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer

6 Jul 2022

Abstract excerpt

Inhibiting the androgen receptor (AR), a ligand-activated transcription factor, with androgen deprivation therapy is a standard-of-care treatment for metastatic prostate cancer. Paradoxically, activation of AR can also inhibit the growth of prostate cancer in some patients and experimental systems, but the mechanisms underlying this phenomenon are poorly understood. This study exploited a potent synthetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Prostate Cancer Treatment and Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36923279
DOI: 10.1158/2767-9764.crc-21-0139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate CancerPMID 36923279Read ↗

H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancerSemantic proximity Read ↗

Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer.Semantic proximity Read ↗

Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostateSemantic proximity Read ↗

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancerSemantic proximity Read ↗

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineagesSemantic proximity Read ↗

A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancerSemantic proximity Read ↗

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cellsSemantic proximity Read ↗

5β-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancerSemantic proximity Read ↗

Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM ComplexSemantic proximity Read ↗

Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate CancerSemantic proximity Read ↗

Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1.Semantic proximity Read ↗

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.