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Article

H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer

18 May 2022

Abstract excerpt

Antiandrogen strategies remain the prostate cancer treatment backbone, but drug resistance develops. We show that androgen blockade in prostate cancer leads to derepression of retroelements (REs) followed by a double-stranded RNA (dsRNA)-stimulated interferon response that blocks tumor growth. A forward genetic approach identified H3K9 trimethylation (H3K9me3) as an essential epigenetic adaptation to...

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PMID: 35584120
DOI: 10.1073/pnas.2114324119

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