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Article

Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability.

Nucleic acids research - 11 Apr 2023

Dervyn Etienne, Planson Anne-Gaëlle, Tanaka Kosei, Chubukov Victor, Guérin Cyprien, Derozier Sandra, Lecointe François, Sauer Uwe, Yoshida Ken-Ichi, Nicolas Pierre, Noirot Philippe, Jules Matthieu

Abstract excerpt

Genome-scale engineering enables rational removal of dispensable genes in chassis genomes. Deviating from this approach, we applied greedy accumulation of deletions of large dispensable regions in the Bacillus subtilis genome, yielding a library of 298 strains with genomes reduced up to 1.48 Mb in size. High-throughput physiological phenotyping of these strains confirmed that genome reduction is associated with...

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PMID: 36919610
DOI: 10.1093/nar/gkad145
PMCID: PMC10085710

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