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Article

Alpha fetoprotein promotes polarization of macrophages towards M2-like phenotype and inhibits macrophages to phagocytize hepatoma cells.

Frontiers in immunology - 1 Jan 2023

Zhang Minni, Liu Kun, Zhang Qiuyue, Xu Junnv, Liu Jinchen, Lin Haifeng, Lin Bo, Zhu Mingyue, Li Mengsen

Abstract excerpt

Alpha-fetoprotein(AFP) is a cancer biomarker for the diagnosis of hepatocellular carcinoma(HCC); however, its role in macrophage polarization and phagocytosis remains unclear. In the present study, we explored the correlation between AFP regulation of macrophage function and the possible regulatory mechanisms. Human mononuclear leukemia cells (THP-1) and monocytes from healthy donors were used to analyze the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36911723
DOI: 10.3389/fimmu.2023.1081572
PMCID: PMC9995430

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