Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.

Journal of hepatology - 1 Mar 2021

Wang Junfeng, Wang Yongchun, Chu Yifan, Li Zhixiong, Yu Xingjuan, Huang Zhijie, Xu Jing, Zheng Limin

Abstract excerpt

BACKGROUND & AIMS: Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-renewal. We aimed to elucidate the contribution, phenotype, and regulatory mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Carcinogenesis
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Liver Neoplasms

Share to Macrophage Activation

Share to Monocytes

Share to Tumor-Associated Macrophages

Source

Identifiers

PMID: 33137360
DOI: 10.1016/j.jhep.2020.10.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.PMID 33137360Read ↗

Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC).Semantic proximity Read ↗

Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implicationsSemantic proximity Read ↗

Coculturing liver cancer cells and monocytes in spheroids conditions monocytes to adopt tumor-associated macrophage phenotypes that favor tumor growth via cholesterol metabolism.Semantic proximity Read ↗

Role of tumor-associated macrophages in the progression of hepatocellular carcinoma.Semantic proximity Read ↗

Macrophages-aPKCι-CCL5 Feedback Loop Modulates the Progression and Chemoresistance in CholangiocarcinomaSemantic proximity Read ↗

High-throughput heterospheroid-based screening identifies drugs that reprogram tumor-associated macrophagesSemantic proximity Read ↗

IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in gliomaSemantic proximity Read ↗

Alpha fetoprotein promotes polarization of macrophages towards M2-like phenotype and inhibits macrophages to phagocytize hepatoma cells.Semantic proximity Read ↗

Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype.Semantic proximity Read ↗

Pharmacological modulation of monocytes and macrophages.Semantic proximity Read ↗

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.Semantic proximity Read ↗

Culture supernatants of cervical cancer cells induce an M2 phenotypic profile in THP-1 macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.