Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.

doi:10.1038/s41588-019-0567-8

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Article

Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.

Nature genetics - 1 Feb 2020

Schlosser Pascal, Li Yong, Sekula Peggy, Raffler Johannes, Grundner-Culemann Franziska, Pietzner Maik, Cheng Yurong, Wuttke Matthias, Steinbrenner Inga, Schultheiss Ulla T, Kotsis Fruzsina, Kacprowski Tim, Forer Lukas, Hausknecht Birgit, Ekici Arif B, Nauck Matthias, Völker Uwe, Walz Gerd, Oefner Peter J, Kronenberg Florian, Mohney Robert P, Köttgen Michael, Suhre Karsten, Eckardt Kai-Uwe, Kastenmüller Gabi, Köttgen Anna

Abstract excerpt

The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify underlying molecular mechanisms, we performed genome-wide association studies of the urinary concentrations of 1,172 metabolites among 1,627 patients with reduced kidney function. The 240 unique metabolite-locus associations (metabolite...

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PMID: 31959995
DOI: 10.1038/s41588-019-0567-8
PMCID: PMC7484970

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